Fresno's Roger Kieschnick had four hits and drove in six runs Wednesday night, leading the Grizzlies to a 10-7 Pacific Coast League win in Albuquerque.
Kieschnick opened the scoring in the second inning with his team-leading 12th home run of the season.
Then in the fifth, with Fresno trailing the Isotopes 3-2, Kieschnick came up with the bases loaded and connected again. His grand slam gave the Grizzlies a 6-3 lead.
Albuquerque had a run in and was threatening for more in the ninth, but Justin Christian made a sensational diving catch in left center for the final out of the game.
The Grizzlies and Isotopes play the final game of the series Thursday in Albuquerque.