The Albuquerque Isotopes beat the Grizzlies in their final at bat Monday night, 3-2.
Albuquerque came back after Fresno overcame a 2-0 deficit in the top of the ninth inning on Francisco Peguero's two run homer. It was his third home run of the season.
The Isotopes then mounted their winning rally in the bottom of the ninth. Luis Cruz capped it with a double to center, driving in Josh Fields for the walkoff winner.
The Grizzlies still own the best record in the Pacific Coast League at 30-14.
The series continues with game two Tuesday night in Albuquerque.